In the wake of cannabidiol’s (CBD) meteoric rise to fame, bulk CBG distillate has emerged as a respectable replacement for, or at least complement to, CBD- and THC-based products intended for medical and recreational purposes.
As a non-intoxicating cannabinoid, cannabigerol is gaining favour among researchers, producers, and consumers. In light of all the buzz, we thought it would be helpful to compile a complete guide to cannabigerol, a novel cannabinoid currently available to consumers.
Cannabigerol (CBG): What Is It Exactly?
CBG distillate in bulk is an amazing compound with great therapeutic potential that was discovered in 1964 and has earned the nickname “mother of all cannabinoids.” One of over a hundred cannabinoids discovered in cannabis. Its acidic form, called cannabigerolic acid (CBGA), is the building block from which other major and minor cannabinoids are synthesised.
CBGA is the acidic chemical precursor of three primary compounds, including:
- THCA stands for tetrahydrocannabinolic acid (THCA)
- Acid Cannabidiol (CBD) (CBDA)
- To put it simply, cannabidiol (CBD) (CBCA)
As the cannabis plant develops, a group of enzymes degrades CBGA to yield these three primary cannabinoids. The majority of the CBGA was transformed into THCA, CBDA, and CBCA by the end of harvest. You can decarboxylate any extra CBGA to get Bulk CBG Distillate. Cannabigerol has a melting point of 118.4 °C (or a boiling point) (52o C).
CBD and its psychoactive counterpart, delta-9 tetrahydrocannabinol, are both found in high concentrations in a fully developed cannabis plant (THC). However, bulk CBG distillate contains less than 1% CBG by dry weight, making it a rare substance. It’s not uncommon for CBD-rich strains to have CBD concentrations of up to 25%. Cannabidiol (THC) concentrations in THC-rich strains typically fall between 25% and 30%.
Since CBG is typically found in much lower concentrations in cannabis plants than THC and CBD, natural products derived from CBG are not as widely available as THC and CBD products. In any case, studies into the curative properties of this remarkable cannabinoid are expanding along with their popularity.
Just how does CBG function?
Endocannabinoid system interaction is mediated by CBG (ECS). The endocannabinoid system is responsible for regulating a wide variety of physiological functions, including but not limited to emotions, sleep, memory, appetite, reproduction, and immune responses.
Cannabinoid CB1 and CB2 receptors are dispersed throughout the body and form the basis of the ECS. The central nervous system and the brain are particularly rich in CB1 receptors. The immune system is a major repository for CB2 receptors.
Particularly, cannabigerol binds to both receptors and boosts the activity of anandamide, the “bliss molecule” neurotransmitter that regulates drive, hunger, sleep, pleasure, and pain.
Increased levels of the neurotransmitter anandamide (AEA) are the result of CBG’s role as a CB1 receptor agonist. In the digestive tract and the immune system, CBG can also interact with CB2 receptors. Research has been unable to determine whether or not it acts as a CB2 agonist or antagonist.
Studies have shown that CBGA affects 5HT1A receptors. This receptor regulates the amount of serotonin in the body. Serotonin signalling in the brain can be moderately impacted by CBG’s ability to block receptors.
Evidence suggests that CBG acts as an adrenoceptor agonist as well. Thanks to this, it is able to control how much noradrenaline and adrenaline are released from the brain. Adrenaline and noradrenaline are the most prominent neurotransmitters in the sympathetic nervous system (SNS).
- Without the psychoactive effects of THC, CBG has the following therapeutic benefits.
- Antimicrobial \sAntibacterial
- Anti-inflammatory
- Anticancer
CBD versus CBG
Many first-time consumers could easily confuse CBD and CBG. CBG shares many of CBD’s therapeutic benefits. CBG and CBD may both be useful in treating a wide variety of conditions and symptoms without inducing euphoria. However, neither CBG nor CBD have any psychoactive effects like THC does. Potentially, they can mitigate the unfavourable effects of THC.
CBD and CBG have different relative concentrations. In the earliest stages of development, CBGA predominates; however, it is gradually converted to CBDA, THCA, and CBCA. High CBD flower buds can have concentrations of up to 25% CBD, while CBG flower buds have concentrations of less than 1% CBD.
Probable Benefits of CBG
Adding cannabigerol to the non-psychoactive cannabinoid cannabidiol has proven to be beneficial. Despite the encouraging results of preliminary studies, more human, peer-reviewed studies of this cannabinoid are required to prove its efficacy. The compound’s full potential can be uncovered by further study in the future.
Syndrome of Inflammation of the Bowel
Those who suffer from inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, deal with persistent inflammation of the digestive tract. One 2013 animal study found that CBG mitigated inflammation and nitric oxide production in the colons of mice. Reactive oxygen species (ROS) production in the gut was also lowered.
Infections that originate from bacteria
Research from 2020 suggests that CBG can effectively combat bacteria. The CBG treatment was especially effective against MRSA (MRSA). Infections caused by methicillin-resistant staph aureus (MRSA) are notoriously challenging to treat because of the staph bacteria’s resistance to multiple antibiotics.
Glaucoma
In a 2008 study on animals, cannabigerol was found to be effective in the treatment of glaucoma. Researchers found that cannabigerol decreased intraocular pressure and increased the outflow of aqueous humour, a fluid that aids in maintaining eye pressure and provides nutrition to the eye.
Disease
Huntington disease is an extremely rare genetic disorder that kills brain cells. In a 2015 study, researchers examined the effects of CBG Distillate Wholesale and other cannabinoids in mice with an experimental model of Huntington’s disease.
According to the results of the study, CBG is a neuroprotective compound that can prevent the death of brain nerve cells. In addition to its neuroprotective properties, it reduced motor deficits and shielded striatal neurons from the toxicity of 3-nitropropionic acid.
A mouse model of colon cancer study published in 2014 found that colon cancer CBGA inhibited tumour growth. By inhibiting the growth of cancer cells, CBG Distillate Wholesale reduces the risk of colon cancer. It inhibited the progression of colorectal cancer cells as well.
a food that stimulates hunger
Among rats, CBG Distillate Wholesale was found to increase food intake in a study conducted in 2016. CBG-treated rats devoured twice as much food as their control group counterparts. HIV patients experiencing chemo-related appetite loss or difficulties may benefit from appetite stimulation.
Bladder Function Impairments
In 2015, researchers examined the effects of cannabinoids on urination. Research has shown that among the various cannabinoids studied for treating bladder dysfunctions, CBG Distillate Wholesale performed the best.
Methods of Using CBG
There has been an increase in the availability of Distillate Wholesale products, especially oil. However, compared to other cannabinoid oils, CBG oils are both rare and costly.
CBG distillate, CBG gummies, and CBG-infused flowers are some of the most popular CBG-based products.
- CBG Tincture Gum CBT
- Tablets of sublingual CBG
- Wholesale CBG Salve and Softgels CBG Concentrate
If you want to benefit from all of the cannabinoids and terpenes naturally present in cannabis plants, you should use full-spectrum or broad-spectrum products.
CBD oil with a full cannabinoid profile is called “broad spectrum” and it includes all cannabinoids except for THC.
The full chemical profile of the strain, including THC, is present in full-spectrum cannabis products.
The term “entourage effect” is used to describe how the positive effects of cannabis are amplified while the negative ones are mitigated by the synergistic interaction between cannabinoids.
Growing and Harvesting Cannabis for Psychoactive Use
Following the passage of the 2018 Farm Bill, hemp cultivation and the manufacturing of hemp derivatives like cannabigerol are now lawful. However, the THC content of the plant and its byproducts can’t be higher than 0.3%.
Wholesale CBG Distillate biomass is processed using hydrocarbon, ethanol, or CO2 extraction to yield cannabigerol oil.
Since CBGA is the first cannabinoid to develop in young cannabis plants, growers must act quickly to harvest hemp plants. Six weeks into a typical eight-week flowering cycle, growers should begin harvesting. There will be the most CBGA present just before it is transformed into a wide range of different cannabinoids.
Cannabigerol is a minor cannabinoid found in trace amounts in cannabis, so even if you harvest at peak cannabigerol concentrations, you’ll still only get a small amount of CBG Distillate to sell wholesale. Additionally, the weight of total cannabinoids is decreased when cannabis is harvested before it is fully mature.
More biomass is needed to produce enough cannabigerol for commercial production. Cannabigerol-based products cost more than comparable cannabinoid products because their production is more labor-intensive.
Breeders have used genetic modification and cross-breeding to develop cannabis strains with increased concentrations of this cannabinoid, in the hopes of increasing yields. The resulting lower extraction costs benefit both manufacturers and consumers. Up to 90% has been found in hemp today. Scientists think that higher concentrations of Wholesale CBG Distillate result from the inability of the drug to be converted to THC due to a defective gene.
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